Bridge Recombinase Mechanism (BRM) utilizes mobile genetic elements or “jumping genes”, which cut and paste themselves into genomes, performing on-the-go DNA manipulation and are present in all forms of life.

• Jumping Genes are small DNA segments with a recombinase enzyme along with extra DNA segments at the ends of the genes that binds and manipulates DNA. 
• Gene editing is alteration of genetic material of a living organism by inserting, replacing, or deleting a DNA sequence, with the aim of improving some characteristic of a plant/ animal or correcting a genetic disorder.

About BRM

• Extra DNA at the ends of jumping genes gets joined together and converts the DNA double helix structure into a single-stranded RNA molecule.
• This bridge RNA molecule can bind to two DNA segments (donor and target), allowing for flexible DNA modifications.
• Donor and target loop can be programmed independently, offering great flexibility in inserting or recombining sequences to DNA.

Significance of BRM

• It will allow researchers to rearrange, recombine, invert, duplicate, move, and perform other editing operations on very long DNA sequences.
•  It can lead to development of more advanced gene editing therapeutics and treatments for diseases.